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  1. Content type: Research

    In this paper, we consider the problem of learning the genetic interaction map, i.e., the topology of a directed acyclic graph (DAG) of genetic interactions from noisy double-knockout (DK) data. Based on a set...

    Authors: Fabio Nikolay, Marius Pesavento, George Kritikos and Nassos Typas

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2017 2017:10

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  2. Content type: Research

    This paper addresses the question of biomarker discovery in proteomics. Given clinical data regarding a list of proteins for a set of individuals, the tackled problem is to extract a short subset of proteins t...

    Authors: Noura Dridi, Audrey Giremus, Jean-Francois Giovannelli, Caroline Truntzer, Melita Hadzagic, Jean-Philippe Charrier, Laurent Gerfault, Patrick Ducoroy, Bruno Lacroix, Pierre Grangeat and Pascal Roy

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2017 2017:9

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  3. Content type: Review

    Stochastic hybrid systems (SHS) have attracted a lot of research interests in recent years. In this paper, we review some of the recent applications of SHS to biological systems modeling and analysis. Due to t...

    Authors: Xiangfang Li, Oluwaseyi Omotere, Lijun Qian and Edward R. Dougherty

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2017 2017:8

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  4. Content type: Research

    Tagging biomedical entities such as gene, protein, cell, and cell-line is the first step and an important pre-requisite in biomedical literature mining. In this paper, we describe our hybrid named entity taggi...

    Authors: Gurusamy Murugesan, Sabenabanu Abdulkadhar, Balu Bhasuran and Jeyakumar Natarajan

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2017 2017:7

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  5. Content type: Review

    The reductionist approach of dissecting biological systems into their constituents has been successful in the first stage of the molecular biology to elucidate the chemical basis of several biological processe...

    Authors: Danila Vella, Italo Zoppis, Giancarlo Mauri, Pierluigi Mauri and Dario Di Silvestre

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2017 2017:6

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  6. Content type: Research

    Electrocardiogram is a slow signal to acquire, and it is prone to noise. It can be inconvenient to collect large number of ECG heartbeats in order to train a reliable biometric system; hence, this issue might ...

    Authors: Wael Louis, Shahad Abdulnour, Sahar Javaher Haghighi and Dimitrios Hatzinakos

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2017 2017:5

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  7. Content type: Research

    Autism spectrum disorder (ASD) is a developmental disorder that significantly impairs patients’ ability to perform normal social interaction and communication. Moreover, the diagnosis procedure of ASD is highl...

    Authors: Jianbo Yuan, Chester Holtz, Tristram Smith and Jiebo Luo

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2017 2017:3

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  8. Content type: Research

    Gene expression time series data are usually in the form of high-dimensional arrays. Unfortunately, the data may sometimes contain missing values: for either the expression values of some genes at some time po...

    Authors: Oyetunji E. Ogundijo, Abdulkadir Elmas and Xiaodong Wang

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2017 2017:2

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  9. Content type: Research

    Methods based on correlation and partial correlation are today employed in the reconstruction of a statistical interaction graph from high-throughput omics data. These dedicated methods work well even for the ...

    Authors: Nurgazy Sulaimanov and Heinz Koeppl

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2016 2016:19

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  10. Content type: Research

    Online community-based health services accumulate a huge amount of unstructured health question answering (QA) records at a continuously increasing pace. The ability to organize these health QA records has bee...

    Authors: Mohammad Akbari, Xia Hu, Liqiang Nie and Tat-Seng Chua

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2016 2016:18

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  11. Content type: Research

    Identifying the residues in a protein that are involved in protein-protein interaction and identifying the contact matrix for a pair of interacting proteins are two computational tasks at different levels of a...

    Authors: Tianchuan Du, Li Liao and Cathy H. Wu

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2016 2016:17

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  12. Content type: Research

    The rapidly expanding corpus of medical research literature presents major challenges in the understanding of previous work, the extraction of maximum information from collected data, and the identification of...

    Authors: Victor Andrei and Ognjen Arandjelović

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2016 2016:16

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  13. Content type: Research

    Principal component analysis (PCA) is a dimensionality reduction and data analysis tool commonly used in many areas. The main idea of PCA is to represent high-dimensional data with a few representative compone...

    Authors: Inci M. Baytas, Kaixiang Lin, Fei Wang, Anil K. Jain and Jiayu Zhou

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2016 2016:15

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  14. Content type: Research

    Prediabetes is a major epidemic and is associated with adverse cardio-cerebrovascular outcomes. Early identification of patients who will develop rapid progression of atherosclerosis could be beneficial for im...

    Authors: Xia Hu, Peter D. Reaven, Aramesh Saremi, Ninghao Liu, Mohammad Ali Abbasi, Huan Liu and Raymond Q. Migrino

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2016 2016:14

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  15. Content type: Research

    Recent years have witnessed an increasing interest in the application of machine learning to clinical informatics and healthcare systems. A significant amount of research has been done on healthcare systems ba...

    Authors: Kuan Wang and Jiebo Luo

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2016 2016:13

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  16. Content type: Research

    By 2050, it is estimated that the number of worldwide Alzheimer’s disease (AD) patients will quadruple from the current number of 36 million, while no proven disease-modifying treatments are available. At pres...

    Authors: Yan Jin, Yi Su, Xiao-Hua Zhou and Shuai Huang

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2016 2016:12

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  17. Content type: Research

    Simulation study in systems biology involving computational experiments dealing with Wnt signaling pathways abound in literature but often lack a pedagogical perspective that might ease the understanding of be...

    Authors: Shriprakash Sinha

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2016 2017:1

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  18. Content type: Research

    Event-related potentials (ERPs) are widely used in brain-computer interface applications and in neuroscience.  Normal EEG activity is rich in background noise, and therefore, in order to detect ERPs, it is usu...

    Authors: William Giroldini, Luciano Pederzoli, Marco Bilucaglia, Simone Melloni and Patrizio Tressoldi

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2016 2016:11

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  19. Content type: Research

    Viral evolution remains to be a main obstacle in the effectiveness of antiviral treatments. The ability to predict this evolution will help in the early detection of drug-resistant strains and will potentially...

    Authors: Mostafa A. Salama, Aboul Ella Hassanien and Ahmad Mostafa

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2016 2016:10

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  20. Content type: Research

    With increasingly “big” data available in biomedical research, deriving accurate and reproducible biology knowledge from such big data imposes enormous computational challenges. In this paper, motivated by rec...

    Authors: Yijie Wang and Xiaoning Qian

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2016 2016:9

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  21. Content type: Research

    RNA interference (RNAi) screening is extensively used in the field of reverse genetics. RNAi libraries constructed using random oligonucleotides have made this technology affordable. However, the new methodolo...

    Authors: Kenta Kamatuka, Masahiro Hattori and Tomoyasu Sugiyama

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2016 2016:7

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  22. Content type: Research

    Tumor size, as indicated by the T-category, is known as a strong prognostic indicator for breast cancer. It is common practice to distinguish the T1 and T2 groups at a tumor size of 2.0 cm. We investigated the...

    Authors: Hiroko K. Solvang, Arnoldo Frigessi, Fateme Kaveh, Margit L. H. Riis, Torben Lüders, Ida R. K. Bukholm, Vessela N. Kristensen and Bettina K. Andreassen

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2016 2016:6

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  23. Content type: Research

    Module identification has been studied extensively in order to gain deeper understanding of complex systems, such as social networks as well as biological networks. Modules are often defined as groups of verti...

    Authors: Siamak Zamani Dadaneh and Xiaoning Qian

    Citation: EURASIP Journal on Bioinformatics and Systems Biology 2016 2016:5

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