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EURASIP Journal on Bioinformatics and Systems Biology
Fig. 3 | EURASIP Journal on Bioinformatics and Systems Biology

Fig. 3

From: From protein-protein interactions to protein co-expression networks: a new perspective to evaluate large-scale proteomic data

Fig. 3

ReactomeFIViz: from disease pathway to PPI network. Main steps to obtain a protein functional and a physical protein network, starting from a specific pathway (oncogene induced senescence). Using ReactomeFIViz, pathways can be visualized in relation with others (a), can be detailed as a diagram showing all intermolecular relationships (b), and as a protein functional interaction network (c) showing just the relation among proteins that cooperate to perform a given molecular function. Finally, starting from a group of protein of interest, it is possible to obtain a network of protein-protein interactions by STRING; in the reported example, the interactions shown are limited to physical type, in particular binding, activation and inhibition (d)

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