Open Access

Compressing Proteomes: The Relevance of Medium Range Correlations

EURASIP Journal on Bioinformatics and Systems Biology20072007:60723

https://doi.org/10.1155/2007/60723

Received: 14 January 2007

Accepted: 10 September 2007

Published: 30 October 2007

Abstract

We study the nonrandomness of proteome sequences by analysing the correlations that arise between amino acids at a short and medium range, more specifically, between amino acids located 10 or 100 residues apart; respectively. We show that statistical models that consider these two types of correlation are more likely to seize the information contained in protein sequences and thus achieve good compression rates. Finally, we propose that the cause for this redundancy is related to the evolutionary origin of proteomes and protein sequences.

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Authors’ Affiliations

(1)
Dipartimento di Matematica, Università di Roma "La Sapienza"
(2)
Structural and Computational Biology Unit, EMBL Heidelberg

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Copyright

© Dario Benedetto et al. 2007

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.