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IB, NF-B Regulation Model: Simulation Analysis of Small Number of Molecules


The regulation of IB, NF-B is of foremost interest in biology as the transcription factor NF-B has multiple target genes. We have modeled a previously published model by Hoffmann et al. (2002) of IB, NF-B mathematically as discrete reaction systems. We have used stochastic algorithm to compare the results when there are large and small numbers of molecules available in a finite volume for each protein. Our results for small number of molecules show that with continuous presence of stimulation, nuclear NF-B oscillates continuously in every individual cell rather than damping, which was observed in cell population results. This characteristic of the system is missed when averaged behavior is studied.



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Correspondence to Anamika Sarkar.

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Sarkar, A., Meila, M. & Franza, R.B. IB, NF-B Regulation Model: Simulation Analysis of Small Number of Molecules. J Bioinform Sys Biology 2007, 25250 (2008).

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  • Transcription Factor
  • Target Gene
  • Cell Population
  • Reaction System
  • Individual Cell