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I B, NF- B Regulation Model: Simulation Analysis of Small Number of Molecules

EURASIP Journal on Bioinformatics and Systems Biology20082007:25250

Received: 21 March 2007

Accepted: 8 November 2007

Published: 24 January 2008


The regulation of I B, NF- B is of foremost interest in biology as the transcription factor NF- B has multiple target genes. We have modeled a previously published model by Hoffmann et al. (2002) of I B, NF- B mathematically as discrete reaction systems. We have used stochastic algorithm to compare the results when there are large and small numbers of molecules available in a finite volume for each protein. Our results for small number of molecules show that with continuous presence of stimulation, nuclear NF- B oscillates continuously in every individual cell rather than damping, which was observed in cell population results. This characteristic of the system is missed when averaged behavior is studied.


Transcription FactorTarget GeneCell PopulationReaction SystemIndividual Cell


Authors’ Affiliations

Bioengineering Department, Cell Systems Initiative, University of Washington, Seattle, USA
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, USA
Statistics Department, University of Washington, Seattle, USA


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© Anamika Sarkar et al. 2007

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.