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Fig. 6 | EURASIP Journal on Bioinformatics and Systems Biology

Fig. 6

From: Analysis of miRNA, mRNA, and TF interactions through network-based methods

Fig. 6

Workflow of analysis in IntegraMiR. IntegraMiR receives as input two lists of miRNA and mRNA expression data grouped into two classes (e.g., healthy vs diseased). Initially, the web server identifies significant differentially expressed (SDE) miRNAs and mRNAs. Then, prior knowledge is used to derive associations among miRNA, mRNA, and TF considering only those extracted in the previous steps. Then, FFLs whose members are differentially expressed are determined. These FFLs are then organized considering the kind of deregulation and ranked by using a statistical approach and visualized to the user

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