Table 5 Concentrations of active CaMKII and PP1 in different simulations. For all the models, the peak concentrations of active CaMKII and PP1 ([CaMKII]_peak, [PP1]_peak) are tabulated together with the concentrations at the end point 2000 s ([CaMKII]_end, [PP1]_end) in units of μ M. Furthermore, percentages from the maximum peak concentration are given separately for each model.

d'Alcantara et al. [16]

0.4999 (3%)

0.0023

1.6276 (38%)

1.5507

Kim et al. [17]

0.2912 (4%)^a

0.2912

1.9634 (40%)

1.9440

Lindskog et al. [18]

0.3617 (13%)

0.0251

1.7157 (36%)

1.6896

Nakano et al. [19]

0.6707 (4%)

0.0173

2.5799 (37%)

1.7584

Hayer and Bhalla [2]

117.9152 (99%)^a

117.9152

2.0009 (40%)^a

0.0002

d'Alcantara et al. [16]

0.9998 (5%)

0.0030

3.3444 (78%)

3.1915

Kim et al. [17]

0.5326 (8%)^a

0.5174

3.9530 (80%)

3.9313

Lindskog et al. [18]

0.6760 (24%)

0.0370

3.7155 (79%)

3.6893

Nakano et al. [19]

1.1637 (6%)

0.0154

4.5621 (65%)

3.6606

Hayer and Bhalla [2]

6.9027 (6%)^a

6.9027

4.0004 (80%)^a

0.1017

d'Alcantara et al. [16]

1.9996 (10%)

0.0052

3.3480 (78%)

3.1744

Kim et al. [17]

1.3295 (19%)^a

1.1511

3.9524 (80%)

3.9295

Lindskog et al. [18]

1.1739 (41%)

0.0737

3.7155 (79%)

3.6892

Nakano et al. [19]

2.1318 (12%)

0.0286

4.5622 (65%)

3.6603

Hayer and Bhalla [2]

6.9032 (6%)^a

6.9032

4.0000 (80%)^a

0.1017

d'Alcantara et al. [16]

3.9996 (20%)

0.0341

0.8032 (19%)

0.7410

Kim et al. [17]

2.5904 (37%)^a

2.5904

0.9749 (20%)

0.9568

Lindskog et al. [18]

1.7671 (61%)

0.3229

0.7160 (15%)

0.6890

Nakano et al. [19]

4.0736 (23%)

0.2068

1.5902 (23%)

0.8950

Hayer and Bhalla [2]

119.3471 (100%)^a

119.3471

1.0006 (20%)^a

0.0001

d'Alcantara et al. [16]

19.9882 (100%)

0.0320

4.2702 (100%)

3.7504

Kim et al. [17]

5.9959 (85%)^a

5.9959

4.9522 (100%)

4.9102

Lindskog et al. [18]

2.8245 (98%)

0.6318

4.7143 (100%)

4.6870

Nakano et al. [19]

18.0171 (100%)

0.1727

6.9654 (100%)

6.0135

Hayer and Bhalla [2]

20.0000 (17%)^a

2.2876

5.0000 (100%)^a

1.2884

d'Alcantara et al. [16]

19.9933 (100%)

0.0686

1.6728 (39%)

1.3771

Kim et al. [17]

7.0283 (100%)^a

7.0283

1.9663 (40%)

1.9331

Lindskog et al. [18]

2.8756 (100%)

0.8772

1.7143 (36%)

1.6862

Nakano et al. [19]

18.0415 (100%)

0.5670

2.5900 (37%)

1.7571

Hayer and Bhalla [2]

115.3967 (97%)^a

115.3967

2.0000 (40%)^a

0.0003