Table 2 Model components. Tabulated characteristics are the compartments, receptors, Ca2+ mechanisms, and signaling pathways modeled. Used abbreviations are adenylyl cyclase (AC), α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR), calmodulin (CaM), calcium/CaM-dependent protein kinase II (CaMKII), calcineurin (CaN), cyclin-dependent kinase 5 (Cdk5), dopamine receptor (D1R), dopamine- and cyclic adenosine monophosphate-regulated neuronal phosphoprotein of 32 kDa (DARPP32), inhibitor 1 (I1), phosphodiesterase type 1 (PDE1), PDE type 1B (PDE1B), PDE type 2 (PDE2), PDE type 4 (PDE4), cyclic adenosine monophosphate-dependent protein kinase (PKA), protein phosphatase 1 (PP1), and protein phosphatase 2A (PP2A).
Model | Compartments | Receptors | Ca2+ mechanisms | Signaling pathways |
|---|---|---|---|---|
d'Alcantara et al. [16] | 1 postsynaptic | AMPAR | CaM buffer | CaM, CaMKII, CaN, I1, PP1 |
Kim et al. [17] | 1 spine | D1R | CaM buffer | CaM, CaMKII, CaN, G protein, I1, PDE1B, PDE4, PKA, PP1 |
Lindskog et al. [18] | 1 spine | D1R | CaM buffer | AC, CaM, CaMKII, CaN, DARPP32, PDE1, PDE4, PKA, PP1, PP2A |
Nakano et al. [19] | 1 spine | AMPAR, D1R | CaM buffer | AC, CaM, CaMKII, CaN, Cdk5, DARPP32, I1, PDE1, PDE2, PKA, PP1, PP2A |
Hayer and Bhalla [2] | 1 dendritic, 1 postsynaptic, 1 spine-head | AMPAR | CaM buffer, 1-D diffusion of some of the molecules | AC, CaM, CaMKII, CaN, PKA, PP1 |