Skip to main content
Figure 6 | EURASIP Journal on Bioinformatics and Systems Biology

Figure 6

From: Stability from Structure: Metabolic Networks Are Unlike Other Biological Networks

Figure 6

(a) and (b) represent comparisons of the B-SSS and the P-SSS. In both plots, the SSSes are ranked according to descending P-SSS. Note that the original P-SSS (for 13 motifs) cannot be compared directly to our B-SSS (for 97 motifs). We defined four SSSes: colored P-SSS, uncolored P-SSS, colored B-SSS, and uncolored B-SSS. The uncolored P-SSS is the original SSS from [5], the colored B-SSS is the SSS discussed in Section 2.8. The colored P-SSS is calculated by sampling positive, negative, and combined interactions from a , and a distribution, respectively. The uncolored B-SSS is calculated by sampling each nonzero, nondiagonal entry and each diagonal entry in the adjacency matrix of a motif from the and distribution given in Section 2.8, respectively. Note that in (a) the B-SSS is always higher than the P-SSS except for the first four motifs, which have a P-SSS of 1, that is, they are always stable, no matter the interaction strengths. (b) shows the same behavior. The difference between the red and green lines is a measure for the change in structural stability for each motif. Therefore, the fluctuation in the B-SSS tells us that some motifs are more affected by changing the distribution used to sample from than others. (c) and (d) represent the effect of edge colors on the two SSSes. The 75 different motifs are sorted according to their ID. The black dashed lines divide the x-axes into 13-motif segments. A segment contains all motifs which have the same ID, and thus structure, but different edge colors, that is, interaction signs. The red lines are the SSS scores for the 97 different motifs, the blue line represents the original SSS score for each motif id. (c) The red line is the B-SSS of the colored model (, Section 2.7), the blue line is the B-SSS of the uncolored model (). (d) The red line is the P-SSS we have created for the colored model, the blue line is the original SSS from [5]. The red line in (a) follows the blue line quite closely, whereas in (b) the similarity is smaller.

Back to article page