Centrality | Description | Biological meaning |
---|---|---|
Diametera | Defines the longest shortest path in the network | Â |
Average distancea | Defines the mean length of all the shortest paths in the network | Â |
Degreeb | Describes the number of neighbors a node has | Highlights the number of nodes that regulated/regulate the node v |
Eccentricityb | Describes the longest shortest paths a node develop, giving us a proximity information | Highlights the easiness of a protein to reach/to be reached by all the other proteins in the network |
Closenessb | Describes, for the node v, the minimal sum of all the distances in the network | Highlights the probability of a protein to be functionally relevant for several proteins, but irrelevant for a few others |
Radialityb | Describes the integration of a node into the network | Highlights the ability of a protein to be functionally relevant for several proteins, but irrelevant for a few others |
Centroidb | Describes the neighborhood of nodes by highlighting nodes that have the highest number of neighbors separated by the minimal shortest path | Highlights a protein that tends to be functionally capable of organizing discrete protein clusters or modules |
Stressb | Describes the number of shortest paths that pass through a node | Highlights the relevance of a protein as functionally capable of holding together communicating nodes |
Betweennessb | Describes, for each couple of nodes, the number of shortest paths that pass through a specific node | Highlights the relevance of a protein as functionally capable of holding together communicating nodes |
Bridgingb | Describes the neighborhood of nodes by highlighting nodes with a high number of high-degree neighbors | Highlights a protein possibly bringing in communication sets of regulatory protein |
Eigenvectorb | Describes a sort of weighted degree, where not only the number of the neighbors is important but also the Eigenvector of the neighbors itself | Highlights a protein interacting with several important proteins, suggesting a central super-regulatory role or a critical target of a regulatory pathways |
Edge betweennessc | Describes, for each couple of nodes, the shortest paths that pass through a specific edge | Highlights the relevance of the interaction as capable of organizing regulatory process |