| Avg. accuracy (%) | Avg. F1 (%) | Avg. MCC (%) | Avg. precision (%) | Avg. recall (%) |
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ipHMM | 94.93 | 75.61 | 73.69 | 77.56 | 76.51 |
CM-ipHMM | 96.97 | 90.05 | 89.11 | 85.98 | 96.83 |
CM-only | 96.30 | 88.52 | 87.23 | 85.22 | 94.91 |
Ground-truth-CM | 99.83 | 99.51 | 99.40 | 99.89 | 99.21 |
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ipHMM the interaction profile hidden Markov model used to prediction interaction site, CM-ipHMM the logistic regression model built with the integration of contact matrix prediction and ipHMM interaction site prediction, CM-only the logistic regression model built with the predicted contact matrix prediction only, Ground-truth-CM the logistic regression model built with the ground-truth contact matrix prediction and ipHMM interaction site prediction