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Table 8 Conditional probability tables for nodes (excluding gene expression) of \(\mathcal {M}_{\text {PBK+EI}}\)

From: A pedagogical walkthrough of computational modeling and simulation of Wnt signaling pathway using static causal models in MATLAB

  

Conditional probability table for nodes

 

Node

Parents

Cpt values rep.

Node states

Sample

-

[0.50 0.50] T

[n t]

T C F4

-

[0.10 0.90] T

[ia a]

D V L2

D A C T3

[0.01 0.99; 0.99 0.01] T

[lc hc]

β-catenin

D A C T1,

[0.99 0.99 0.99 0.01;

[lc hc]

 

D V L2

0.01 0.01 0.01 0.99] T

 

TRCMPLX

T C F4, L E F1,

[0.99*ones(1,7) 0.01;

[ia a]

 

β-catenin

0.01*ones(1,7) 0.99] T

 

M e D A C T1

-

[0.8370 0.1630] T

[nm m]

M e D A C T2

-

[0.3376 0.6624] T

[nm m]

M e W I F1

-

[0.1667 0.8333] T

[nm m]

M e S F R P1

-

[0.6316 0.3684] T

[nm m]

M e S F R P2

-

[0.6316 0.3684] T

[nm m]

M e S F R P4

-

[0.8572 0.1428] T

[nm m]

M e S F R P5

-

[0.7500 0.2500] T

[nm m]

H3K27m e3

-

[0.2391 0.7609] T

[ia a]

H3K4m e3

-

[0.3661 0.6339] T

[ia a]

  1. Notations in the table mean the following “-” implies no parents exist for the particular node; “n” - normal, “t” - tumorous, “ia” - inactive, “a” - active, “lc” - low concentration, “hc” - high concentration, “nm” - non-methylated, “m” - methylation