EURASIP Journal on Bioinformatics and Systems Biology

Table 3 Regulatory relationships of a p53 signaling network

From: Optimal cancer prognosis under network uncertainty

Gene/protein/signal	Predictors: regulatory type (+ / −)
DNAdamage	DNAdamage: +
p53	ATR: +, CHEK1: +, CHEK2: +,
	MDM2: −, MDMX: −
p14ARF	p14ARF: +
ATR	DNAdamage: +
ATM	DNAdamage: +
CHEK1	ATR: +
CHEK2	ATM: +
MDM2	p14ARF: −, MDMX: +
MDMX	MDM2: −

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