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Table 1 Parameter settings in simulation of biomarker validation model

From: Modeling and systematic analysis of biomarker validation using selected reaction monitoring

Parameter Defaults value
Number of classes 2
Sample size n=80
Block size b=5
Block correlation ρ=0.8
Fold change h=2, a i U n i f(1,2)
Modification noise αpm=0.03,βpm=3.6
Peptide efficiency factor αpe=0.5,e i U(0.5,1)
Gamma parameters t c =2,θ c =100,t a =5,θ a =10e 6
Purification β γ =10e−6
Protein mixture N a pr =250, N c pr =40
Ranking power d=2, r=0.01