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Figure 3 | EURASIP Journal on Bioinformatics and Systems Biology

Figure 3

From: Modeling and systematic analysis of biomarker validation using selected reaction monitoring

Figure 3

Workflow of an SRM experiment. First, a set of proteins of interest are determined for a specific study. Then, for each protein, some proteotypic peptides are found. In the next step, for each PTP, those fragments that are able to discriminate the peptide from others are found. The transitions (pairs of m/z values for precursor/fragment ions) are then validated to decrease the effect of unspecific signals.

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