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Table 6 Frequent templates are more successful than others

From: Template-based intervention in Boolean network models of biological systems

  Top 1,000 Random 1,000 Z-score Pvalue
Basin 1 4,493 4,293 2.753 0.00298
Basin 2 3,838 1,783 31.767 0.00000
Basin 3 2,534 1,073 26.605 0.00000
Basin 4 4,520 3,378 16.050 0.00000
  Top 1,000 Bottom 1,000 Z-score P value
Basin 1 4,493 1,979 37.196 0.00000
Basin 2 3,838 8 67.986 0.00000
Basin 3 2,534 1,000 28.166 0.00000
Basin 4 4,520 2,315 32.124 0.00000
  1. Listed in the table are intervention success counts, Z-scores and P values for two-proportion Z-tests between the top 1,000 most frequent 3-templates and 1,000 random templates or the 1,000 least frequent templates. With 11 intervention starting states over 1,000 templates, each number of successes is out of 11,000 intervention attempts. In each case we find, with statistical confidence, the top frequency template group provides a higher proportion of successful interventions than the other groups.