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Table 6 Frequent templates are more successful than others

From: Template-based intervention in Boolean network models of biological systems

 

Top 1,000

Random 1,000

Z-score

Pvalue

Basin 1

4,493

4,293

2.753

0.00298

Basin 2

3,838

1,783

31.767

0.00000

Basin 3

2,534

1,073

26.605

0.00000

Basin 4

4,520

3,378

16.050

0.00000

 

Top 1,000

Bottom 1,000

Z-score

P value

Basin 1

4,493

1,979

37.196

0.00000

Basin 2

3,838

8

67.986

0.00000

Basin 3

2,534

1,000

28.166

0.00000

Basin 4

4,520

2,315

32.124

0.00000

  1. Listed in the table are intervention success counts, Z-scores and P values for two-proportion Z-tests between the top 1,000 most frequent 3-templates and 1,000 random templates or the 1,000 least frequent templates. With 11 intervention starting states over 1,000 templates, each number of successes is out of 11,000 intervention attempts. In each case we find, with statistical confidence, the top frequency template group provides a higher proportion of successful interventions than the other groups.