A comparison study of optimal and suboptimal intervention policies for gene regulatory networks in the presence of uncertainty

EURASIP Journal on Bioinformatics and Systems Biology

Table 3 Boolean regulatory functions of a mutated mammalian cell cycle

Gene	Node	Predictor functions
CycD	v ₁	Extracellular signal
Rb	v ₂	$(\bar{v_{1}} \land \bar{v_{4}} \land \bar{v_{5}} \land \bar{v_{9}})$
E2F	v ₃	$(\bar{v_{2}} \land \bar{v_{5}} \land \bar{v_{9}})$
CycE	v ₄	$(v_{3} \land \bar{v_{2}})$
CycA	v ₅	$(v_{3} \land \bar{v_{2}} \land \bar{v_{6}} \land (\bar{v_{7} \land v_{8}})) \lor (v_{5} \land \bar{v_{2}} \land \bar{v_{6}} \land (\bar{v_{7} \land v_{8}}))$
Cdc20	v ₆	v ₉
Cdh1	v ₇	$(\bar{v_{5}} \land \bar{v_{9}}) \lor v_{6}$
UbcH10	v ₈	$\bar{v_{7}} \lor (v_{7} \land v_{8} \land (v_{6} \lor v_{5} \lor v_{9}))$
CycB	v ₉	$(\bar{v_{6}} \land \bar{v_{7}})$