Figure 2
From: Identification of thresholds for dichotomizing DNA methylation data
An example of StepMiner2D. (a) Scatter plot of ESR1’s gene expression and methylation. The dotted lines indicate threshold identified by StepMiner2D. (b) Scatter plot of rank transformed data. (c) Heatmap showing a non-decreasing surface sitting on top of the rank transformed data. (d) Three-dimensional visualization of points on the non-decreasing surface and the best fit bivariate step function.