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EURASIP Journal on Bioinformatics and Systems Biology
Figure 2 | EURASIP Journal on Bioinformatics and Systems Biology

Figure 2

From: Protein network-based Lasso regression model for the construction of disease-miRNA functional interactions

Figure 2

Predicted disease-miRNA functional association. Predicted miRNA-disease interactions using Lasso regression model. Here we used combined microarray and abstract disease gene signature as response variable and with PPI-based miRNA-target signatures predicted variable. We mapped all the common interactions between the predicted interactions and the gold standard data. We also showed the novel interaction predicted by our model and the interactions missed by our model. Results showed that results are biased to cancer diseases(prostate, breast, ovary, glioblastoma, melanoma as they have more complete gene signatures.

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