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EURASIP Journal on Bioinformatics and Systems Biology
Figure 1 | EURASIP Journal on Bioinformatics and Systems Biology

Figure 1

From: Protein network-based Lasso regression model for the construction of disease-miRNA functional interactions

Figure 1

An overview of the framework and flow of data. Four major steps to construct functional disease-miRNA associations. First is disease-gene interactions that were constructed by integrating disease signatures from microarray gene expression data and from pubmed abstracts. Second, miRNA-gene associations was constructed by integrating computationally predicted miRNA-target interactions and protein networks. The aim of integrating protein networks is to reduce noisiness in the predicted data. Proteins that are not targeted by a miRNA but their partners are, are considered as indirect miRNA-target association. Third step is to process the two input (gene-disease and miRNA-gene) as input to the Lasso regression model. The final step is to evaluate the predicted results against gold standard miRNA-target interactions data.

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