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Table 1 Top ten gain/loss spatial functional hotspots (SFHs) of HCC with enriched functions

From: Identification of genomic functional hotspots with copy number alteration in liver cancer

Chr

Start pos

End pos

Number of CNVs

 

Presented gene set

Number gene sets

Gain

      

 1

153.33

153.59

59

bp

Response to lipopolysaccharide

4

 1

153.27

153.43

59

bp

Innate immune response

4

 1

153.33

153.36

59

bp

Response to zinc ion

2

 1

152.27

153.43

59

bp

Epidermis development

13

 1

152.27

153.23

59

mf

Structural molecule activity

8

 1

152.88

153.43

58

bp

Keratinocyte differentiation

12

 1

152.88

153.23

58

bp

Peptide cross-linking

6

 1

152.88

153.23

58

mf

Protein binding, bridging

4

 1

153.50

153.60

57

mf

Protein homodimerization activity

5

 1

153.50

153.60

57

cc

Perinuclear region of cytoplasm

5

Loss

      

 8

6.84

6.88

42

bp

Response to virus

3

 4

190.39

191.01

40

mf

Sequence-specific DNA binding

6

 4

190.39

191.01

40

mf

Sequence-specific DNA binding transcription Factor activity

6

 8

6.35

6.91

40

cc

Extracellular space

7

 4

90.80

91.76

40

cc

Platelet alpha granule lumen

2

 4

90.80

91.76

40

bp

Platelet degranulation

2

 8

26.61

27.47

39

bp

Response to stress

3

 17

10.35

10.56

38

bp

Actin filament-based movement

2

 8

26.37

27.31

37

bp

Response to cocaine

2

 8

22.88

23.08

37

mf

Caspase activator activity

2

  1. Immune-related functions are in italics.