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Table 1 Top ten gain/loss spatial functional hotspots (SFHs) of HCC with enriched functions

From: Identification of genomic functional hotspots with copy number alteration in liver cancer

Chr Start pos End pos Number of CNVs   Presented gene set Number gene sets
Gain       
 1 153.33 153.59 59 bp Response to lipopolysaccharide 4
 1 153.27 153.43 59 bp Innate immune response 4
 1 153.33 153.36 59 bp Response to zinc ion 2
 1 152.27 153.43 59 bp Epidermis development 13
 1 152.27 153.23 59 mf Structural molecule activity 8
 1 152.88 153.43 58 bp Keratinocyte differentiation 12
 1 152.88 153.23 58 bp Peptide cross-linking 6
 1 152.88 153.23 58 mf Protein binding, bridging 4
 1 153.50 153.60 57 mf Protein homodimerization activity 5
 1 153.50 153.60 57 cc Perinuclear region of cytoplasm 5
Loss       
 8 6.84 6.88 42 bp Response to virus 3
 4 190.39 191.01 40 mf Sequence-specific DNA binding 6
 4 190.39 191.01 40 mf Sequence-specific DNA binding transcription Factor activity 6
 8 6.35 6.91 40 cc Extracellular space 7
 4 90.80 91.76 40 cc Platelet alpha granule lumen 2
 4 90.80 91.76 40 bp Platelet degranulation 2
 8 26.61 27.47 39 bp Response to stress 3
 17 10.35 10.56 38 bp Actin filament-based movement 2
 8 26.37 27.31 37 bp Response to cocaine 2
 8 22.88 23.08 37 mf Caspase activator activity 2
  1. Immune-related functions are in italics.