Approximate maximum likelihood estimation for stochastic chemical kinetics

EURASIP Journal on Bioinformatics and Systems Biology

Table 1 Different approximations of the standard deviations of the estimators

Method	K	R	c ₁	c ₂	c ₃	σ	mRNA(0)
Fisher inf. matrix	10	10	0.0545104	0.561963	0.935324	0.364339	0.639471
100 experiments			0.0358142	0.198700	0.262223	0.392884	0.490305
Fisher inf. matrix	20	20	0.0324508	0.299487	0.451476	0.174095	0.594820
100 experiments			0.0304157	0.167431	0.287471	0.134506	0.436059
Fisher inf. matrix	50	50	0.0139185	0.110709	0.152229	0.0440282	0.238033
100 experiments			0.0140331	0.078516	0.146232	0.0353837	0.183888
Fisher inf. matrix	100	100	0.00866066	0.0548249	0.0728129	0.0182564	0.208469
100 experiments			0.00691956	0.0430123	0.0641821	0.0217544	0.187968