Figure 5
From: Statistical discovery of site inter-dependencies in sub-molecular hierarchical protein structuring
TTR cluster tree. The above diagram shows clusters of mutually associated sites found within a multiple sequence alignment for transthyretin, composed of 465 non-redundant sequences. It is remarkable that although some of the branches converge to a large node forming a major module, many of the branches do not converge to large nodes. This suggests that much of Transthyretin lacks the structural stability that comes with large nodes composed of many interdependent branches. This may provide insight as to why Transthyretin is susceptible to misfolding.