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Table 2 Parameter values

From: Dynamical modeling of drug effect using hybrid systems

Parameter Reaction type Biochemical reaction Value Unit
a 4 Complex formation N F − κ B + I κ B α → N F − κ B : I κ B α 30 μ M−1min−1
a 7 Complex formation N F − κ B : I κ B α + I K K → N F − κ B : I κ B α : I K K 11.1 μ M−1min−1
a 1 Complex formation I κ B α + I K K → I κ B α : I K K 1.38 μ M−1min−1
d 4 Dissociation N F − κ B + I κ B α ← N F − κ B : I κ B α 0.03 min-1
D 1 Dissociation N F − κ B : I κ B α + I K K ← N F − κ B : I κ B α : I K K 0.075 min-1
D 1 Dissociation I κ B α + I K K ← I κ B α : I K K 0.075 min-1
d e g 1 Degradation I κ B α → 0 0.006 min-1
d e g 4 Degradation N F − κ B : I κ B α → N F − κ B 0.0013 min-1
k 01 Transport N F − κ B n → N F − κ B 0.0048 min-1
t p 2 Transport I κ B α n → I κ B α 0.025 min-1
k 2 Transport N F − κ B n : I κ B α n → N F − κ B : I κ B α 0.84 min-1
k 1 Transport N F − κ B → N F − κ B n 5.4 min-1
t p 1 Transport I κ B α → I κ B α n 0.05 min-1
τ Synthesis (delay) N F − κ B n → N F − κ B n + I κ B α 40 min
k 02 Inactivation I K K → 0 0.002 min-1
r4+d4 Catalyzed degradation N F − κ B : I κ B α : I K K → N F − κ B + I K K 11.1 min-1
r 1 Catalyzed degradation I κ B α : I K K → I K K 2.22 min-1
s synthesis Synthesis N F − κ B n → N F − κ B n + I κ B α 0.24 min-1