Table 2 Parameter values
From: Dynamical modeling of drug effect using hybrid systems
Parameter | Reaction type | Biochemical reaction | Value | Unit |
|---|---|---|---|---|
a 4 | Complex formation | N F − κ B + I κ B α → N F − κ B : I κ B α | 30 | μ M−1min−1 |
a 7 | Complex formation | N F − κ B : I κ B α + I K K → N F − κ B : I κ B α : I K K | 11.1 | μ M−1min−1 |
a 1 | Complex formation | I κ B α + I K K → I κ B α : I K K | 1.38 | μ M−1min−1 |
d 4 | Dissociation | N F − κ B + I κ B α ← N F − κ B : I κ B α | 0.03 | min-1 |
D 1 | Dissociation | N F − κ B : I κ B α + I K K ← N F − κ B : I κ B α : I K K | 0.075 | min-1 |
D 1 | Dissociation | I κ B α + I K K ← I κ B α : I K K | 0.075 | min-1 |
d e g 1 | Degradation | I κ B α → 0 | 0.006 | min-1 |
d e g 4 | Degradation | N F − κ B : I κ B α → N F − κ B | 0.0013 | min-1 |
k 01 | Transport | N F − κ B n → N F − κ B | 0.0048 | min-1 |
t p 2 | Transport | I κ B α n → I κ B α | 0.025 | min-1 |
k 2 | Transport | N F − κ B n : I κ B α n → N F − κ B : I κ B α | 0.84 | min-1 |
k 1 | Transport | N F − κ B → N F − κ B n | 5.4 | min-1 |
t p 1 | Transport | I κ B α → I κ B α n | 0.05 | min-1 |
τ | Synthesis (delay) | N F − κ B n → N F − κ B n + I κ B α | 40 | min |
k 02 | Inactivation | I K K → 0 | 0.002 | min-1 |
r4+d4 | Catalyzed degradation | N F − κ B : I κ B α : I K K → N F − κ B + I K K | 11.1 | min-1 |
r 1 | Catalyzed degradation | I κ B α : I K K → I K K | 2.22 | min-1 |
s synthesis | Synthesis | N F − κ B n → N F − κ B n + I κ B α | 0.24 | min-1 |