Figure 19
From: Dynamical modeling of drug effect using hybrid systems
Simulation results for the NF−κB pathway under various drug perturbations with different drug administration. (a) Effect of continuous stimulus, no drug input. (b) Effect of drug X (0.2 μ M). (c) Effect of drug X (1.0 μ M). (d) Effect of Bortezomib (65% inhibition). (e) Effect of Bortezomib (95% inhibition). (f) Effect of combined Bortezomib (65% inhibition) and drug X (0.2 μ M). The detailed parameters are available in the Appendix.