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Figure 8 | EURASIP Journal on Bioinformatics and Systems Biology

Figure 8

From: In vitro detection of adrenocorticotropic hormone levels by fluorescence correlation spectroscopy immunoassay for mathematical modeling of glucocorticoid-mediated feedback mechanisms

Figure 8

Fit of the experimental data by means of the multicompartment model. The graph shows the result of the parameter fitting for the extended mathematical model, including the membrane receptors for cortisol and CRH. The identified parameters allow to reproduce the observed dynamics in the two scenarios, i.e., with and without cortisol. Hence, by using different initial values for the ODE state variable both characteristic dynamics can be simulated with the same set of parameters. In particular, in the presence of cortisol the fast negative feedback can be reproduced, leading to the experimentally observed sigmoidal curve.

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