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EURASIP Journal on Bioinformatics and Systems Biology
Figure 7 | EURASIP Journal on Bioinformatics and Systems Biology

Figure 7

From: In vitro detection of adrenocorticotropic hormone levels by fluorescence correlation spectroscopy immunoassay for mathematical modeling of glucocorticoid-mediated feedback mechanisms

Figure 7

Fit of the experimental data by means of the parsimonious model from[10]. The figure shows the result of a numerical experiment for the obtained experimental data and the mathematical model as published in [10]. The first (left) plot shows the result of a parameter fit for the dataset without added cortisol. The second (middle) plot shows the reproduction of the ACTH response curve in the presence of CRH and cortisol. The last (right) plot presents the result when considering both experimental datasets at once. The poor quality of the obtained fit in the latter case indicates that the parsimonious model is not capable to reproduce the fast and slow dynamics related to the negative feedback via cortisol.

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