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Table 1 The characteristics of the obtained models

From: Relationships between kinetic constants and the amino acid composition of enzymes from the yeast Saccharomyces cerevisiae glycolysis pathway

Regression model

Dependent variable

Parametersa

Regression coefficient

S.E.

t value

P value

R2%

Radjusted2%

VIFb

R2%c

Radjusted2%c

I

log(kcat)

constant

5.2073

0.5003

10.408

0.0000

95.58

94.11

 

90.72

90.10

  

M

−1.6219

0.1169

−13.879

0.0000

  

1.853

  
  

W

−0.5258

0.2147

−2.449

0.0307

  

3.329

  
  

R

0.3558

0.07329

4.855

0.0004

  

1.103

  
  

L

−0.1697

0.06309

−2.691

0.0196

  

2.180

  

II

log(kcat)

constant

3.9385

1.3200

2.984

0.0124

95.22

93.05

 

80.32

79.01

  

T

−0.4482

0.07274

−6.161

0.0001

  

2.851

  
  

V

0.2756

0.05350

5.151

0.0003

  

1.530

  
  

H

−1.3861

0.2088

−6.639

0.0000

  

2.003

  
  

A

0.2840

0.06859

4.141

0.0016

  

1.868

  
  

K

−0.2333

0.09633

−2.422

0.0339

  

2.857

  

III

log(kcat)

constant

−6.3103

1.7275

−3.653

0.0033

89.30

85.74

 

71.62

69.73

  

A

0.4367

0.07955

5.489

0.0001

  

1.224

  
  

H

−0.9759

0.3015

−3.237

0.0071

  

2.034

  
  

V

0.2728

0.07752

3.519

0.0042

  

1.564

  
  

E

0.5900

0.1564

3.773

0.0027

  

1.498

  

IV

log(KM)

constant

13.2588

0.8236

16.098

0.0000

97.88

96.70

 

93.18

92.66

  

D

−1.1379

0.06612

−17.209

0.0000

  

1.365

  
  

N

−0.9961

0.07256

−13.729

0.0000

  

1.932

  
  

W

1.0535

0.08387

12.561

0.0000

  

1.948

  
  

L

−0.2347

0.03077

−7.628

0.0002

  

2.140

  
  

A

−0.09888

0.02288

−4.321

0.0019

  

1.093

  

V

log(kcat/KM)

constant

−11.0119

1.5657

−7.052

0.0001

97.77

96.29

 

88.86

88.06

  

A

−0.5525

0.05736

9.632

0.0000

  

1.705

  
  

H

−1.2042

0.1817

−6.626

0.0001

  

2.082

  
  

R

1.1894

0.1006

11.829

0.0000

  

2.373

  
  

G

0.6911

0.09445

7.317

0.0000

  

2.520

  
  

Q

−0.5142

0.1009

−5.098

0.0006

  

1.672

  
  

N

0.4252

0.1246

3.412

0.0077

  

2.176

  

VI

log(kcat/KM)

constant

9.4887

0.8188

11.589

0.0000

97.69

96.15

 

88.86

88.07

  

L

−0.4399

0.05548

−7.929

0.0000

  

1.902

  
  

T

−0.9367

0.07023

−13.338

0.0000

  

3.267

  
  

N

1.1552

0.1032

11.194

0.0000

  

1.437

  
  

W

−1.0394

0.2182

−5.012

0.0007

  

3.420

  
  

Q

−0.3207

0.1191

−2.692

0.0247

  

2.244

  
  

F

−0.2690

0.09349

−2.877

0.0183

  

1.349

  

VII

log(kcat/KM)

constant

2.5597

0.8288

3.088

0.0115

97.00

96.50

 

90.44

89.77

  

T

−0.8156

0.06297

−12.953

0.0000

  

2.249

  
  

Q

−0.7700

0.1050

−7.331

0.0000

  

1.495

  
  

C

2.4452

0.2845

8.593

0.0000

  

3.581

  
  

N

0.5745

0.1162

4.943

0.0006

  

1.561

  
  

A

0.2605

0.06600

3.946

0.0027

  

2.027

  
  1. Elements and the statistical indices for multiple linear regression models which link the log-values of kinetic constants and the AAC of the yeast S. cerevisiae enzyme sequences.
  2. a Elements of multiple linear regression which represent the frequencies of AA (a single letter code) occurrence in the yeast S. cerevisiae enzyme sequences and the constant (intercept) of equation.
  3. b The variance inflation factor which indicates the impact of multicollinearity between the independent variables[22].
  4. c Obtained by the LOOCV[21] of models.