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Table 1 The characteristics of the obtained models

From: Relationships between kinetic constants and the amino acid composition of enzymes from the yeast Saccharomyces cerevisiae glycolysis pathway

Regression model Dependent variable Parametersa Regression coefficient S.E. t value P value R2% Radjusted2% VIFb R2%c Radjusted2%c
I log(kcat) constant 5.2073 0.5003 10.408 0.0000 95.58 94.11   90.72 90.10
   M −1.6219 0.1169 −13.879 0.0000    1.853   
   W −0.5258 0.2147 −2.449 0.0307    3.329   
   R 0.3558 0.07329 4.855 0.0004    1.103   
   L −0.1697 0.06309 −2.691 0.0196    2.180   
II log(kcat) constant 3.9385 1.3200 2.984 0.0124 95.22 93.05   80.32 79.01
   T −0.4482 0.07274 −6.161 0.0001    2.851   
   V 0.2756 0.05350 5.151 0.0003    1.530   
   H −1.3861 0.2088 −6.639 0.0000    2.003   
   A 0.2840 0.06859 4.141 0.0016    1.868   
   K −0.2333 0.09633 −2.422 0.0339    2.857   
III log(kcat) constant −6.3103 1.7275 −3.653 0.0033 89.30 85.74   71.62 69.73
   A 0.4367 0.07955 5.489 0.0001    1.224   
   H −0.9759 0.3015 −3.237 0.0071    2.034   
   V 0.2728 0.07752 3.519 0.0042    1.564   
   E 0.5900 0.1564 3.773 0.0027    1.498   
IV log(KM) constant 13.2588 0.8236 16.098 0.0000 97.88 96.70   93.18 92.66
   D −1.1379 0.06612 −17.209 0.0000    1.365   
   N −0.9961 0.07256 −13.729 0.0000    1.932   
   W 1.0535 0.08387 12.561 0.0000    1.948   
   L −0.2347 0.03077 −7.628 0.0002    2.140   
   A −0.09888 0.02288 −4.321 0.0019    1.093   
V log(kcat/KM) constant −11.0119 1.5657 −7.052 0.0001 97.77 96.29   88.86 88.06
   A −0.5525 0.05736 9.632 0.0000    1.705   
   H −1.2042 0.1817 −6.626 0.0001    2.082   
   R 1.1894 0.1006 11.829 0.0000    2.373   
   G 0.6911 0.09445 7.317 0.0000    2.520   
   Q −0.5142 0.1009 −5.098 0.0006    1.672   
   N 0.4252 0.1246 3.412 0.0077    2.176   
VI log(kcat/KM) constant 9.4887 0.8188 11.589 0.0000 97.69 96.15   88.86 88.07
   L −0.4399 0.05548 −7.929 0.0000    1.902   
   T −0.9367 0.07023 −13.338 0.0000    3.267   
   N 1.1552 0.1032 11.194 0.0000    1.437   
   W −1.0394 0.2182 −5.012 0.0007    3.420   
   Q −0.3207 0.1191 −2.692 0.0247    2.244   
   F −0.2690 0.09349 −2.877 0.0183    1.349   
VII log(kcat/KM) constant 2.5597 0.8288 3.088 0.0115 97.00 96.50   90.44 89.77
   T −0.8156 0.06297 −12.953 0.0000    2.249   
   Q −0.7700 0.1050 −7.331 0.0000    1.495   
   C 2.4452 0.2845 8.593 0.0000    3.581   
   N 0.5745 0.1162 4.943 0.0006    1.561   
   A 0.2605 0.06600 3.946 0.0027    2.027   
  1. Elements and the statistical indices for multiple linear regression models which link the log-values of kinetic constants and the AAC of the yeast S. cerevisiae enzyme sequences.
  2. a Elements of multiple linear regression which represent the frequencies of AA (a single letter code) occurrence in the yeast S. cerevisiae enzyme sequences and the constant (intercept) of equation.
  3. b The variance inflation factor which indicates the impact of multicollinearity between the independent variables[22].
  4. c Obtained by the LOOCV[21] of models.