The changes of explained variance upon the growing number of variables in the models. Relationships between an increase in the percentage of explained variance and the number of independent variables (AA frequencies of occurrence) included in multiple regressions, where A and B represent the variety of cases for log(k cat) and log(K M), respectively. Variables in the models: model I: 1 – M, 2 – M, W, 3 – M, W, R, and 4 – M, W, R, L; model II: 1 – T, 2 – T, V, 3 – T, V, H, 4 – T, V, H, A, and 5 – T, V, H, A, K; model III: 1 – H, 2 – H, A, 3 – H, A, E, and, 4 – H, A, E, V; model IV: 1 – D, 2 – D, N, 3 – D, N, W, 4 – D, N, W, L, and 5 – D, N, W, L, A.