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Figure 3 | EURASIP Journal on Bioinformatics and Systems Biology

Figure 3

From: The role of feedback control mechanisms on the establishment of oscillatory regimes in the Ras/cAMP/PKA pathway in S. cerevisiae

Figure 3

Activation of the feedback on Ira2: cAMP oscillations starting from a steady state condition. The occurrence of oscillatory regimes in the cAMP dynamics is only affected by the activation of negative feedback mechanisms and is independent of the initial condition of the system. The plots show the establishment of stable oscillations in cAMP amount (left), as well as in Ras2-GTP and active PKA amounts (right), starting the simulation from an initial condition where the system is at a stable steady state. In this simulation, the initial amounts of cAMP, Ras2-GTP and active PKA are around 47,000, 50, and 400 molecules, respectively.

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