Figure 16

cAMP dynamics obtained with different initial amounts of Cdc25 and GTP. The figure shows the dynamics of cAMP with different initial amounts of Cdc25 and GTP, as given in Figure 15, where A: Cdc25 = 10, GTP = 1.9×10⁴; B: Cdc25 = 10, GTP = 5.0×10⁶; C: Cdc25 = 600, GTP = 1.9×10⁴; D: Cdc25 = 600, GTP = 5.0×10⁶ molecules. The plots show that low amounts of Cdc25 (A and B), or high amounts of Cdc25 coupled with low amounts of GTP (C), lead to the production of very low amounts of cAMP, showing a noisy dynamics. On the other hand, when the amounts of both Cdc25 and GTP are high (D), we observe a dynamics of cAMP similar to that obtained without the feedback on Ira2 proteins (see Figure 2, top left), and no oscillations are established.