Figure 14

Frequency modulation of cAMP oscillations in the wild type condition and under the deletion of Pde1 and Pde2. The figure shows the comparison of the oscillations frequency of cAMP in the wild type condition (red square dots) and under the deletion of Pde1 (green circle dots) or Pde2 (blue diamond dots), with respect to the ratio Cdc25/Ira2 (with the initial amount of Cdc25 ranging from 100 to 600 molecules, and Ira2 = 200 molecules). The plot shows that the deletion of Pde1 has a minor effect with respect to the wild type condition on the modulation of frequency, while the deletion of Pde2 is able to diminish the oscillations frequency of cAMP. For values of the ratio Cdc25/Ira2 greater than 1.5, the points related to the wild type condition are not plotted, since no stable oscillations are established in these cases [17].