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Table 3 Estimated probability of the rare event and the sample variance σ2 as well as the CPU TIME (in s) with 106 runs of the wNRMps, the wSSAps and the refined wSSA for the enzyme futile cycle model (35): (a) θ = 25 and (b) θ = 40

From: Weighted next reaction method and parameter selection for efficient simulation of rare events in biochemical reaction systems

(a)

σ 2

Time

wNRMps

1.74 × 10-7

1.81 × 10-13

4183.2

wSSAps

1.74 × 10-7

1.80 × 10-13

5316.9

Refined wSSA

1.74 × 10-7

1.61 × 10-13

5337.2

(b)

σ 2

Time

wNRMps

4.21 × 10-2

1.51 × 10-3

3589.4

wSSAps

4.21 × 10-2

1.51 × 10-3

4388.3

Refined wSSA

4.21 × 10-2

1.51 × 10-3

4406.6