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Table 1 Estimated probability of the rare event and the sample variance σ2 as well as the CPU time (in s) with 107 runs of the wNRMps, the wSSAps and the refined wSSA for the single species production-degradation model (31): (a) θ = 65 and 70 and (b) θ = 75 and 80

From: Weighted next reaction method and parameter selection for efficient simulation of rare events in biochemical reaction systems

(a)

θ= 65

θ= 70

 

σ 2

Time

σ 2

Time

wNRMps

2.29 × 10-3

5.09 × 10-6

14472

1.68 × 10-4

3.40 × 10-8

16140

wSSAps

2.29 × 10-3

5.10 × 10-6

16737

1.68 × 10-4

3.40 × 10-8

18555

Refined wSSA

2.29 × 10-3

3.39 × 10-5

24340

1.68 × 10-4

4.29 × 10-7

25492

(b)

θ = 75

θ = 80

 

σ 2

Time

σ 2

Time

wNRMps

8.42 × 10-6

1.10 × 10-10

15640

2.99 × 10-7

1.82 × 10-13

16260

wSSAps

8.42 × 10-6

1.10 × 10-10

18582

2.99 × 10-7

1.82 × 10-13

18960

Refined wSSA

8.43 × 10-6

3.58 × 10-9

26314

2.99 × 10-7

1.29 × 10-11

26987