Table 4 Changed initial and total concentrations related to different states of CaMKII and PP1 to reach the total concentrations given in Table 3 . Other values used in the simulations are based on the original models. We use here the actual names of the variables and constants as given in the model code downloaded from a database. Values are given in units of μ M.
Model | Sim1 | Sim2 | Sim3 | Sim4 | Sim5 | Sim6 |
|---|---|---|---|---|---|---|
d'Alcantara et al. [16] | Naive states set to total, others zero | Naive states set to total, others zero | Naive states set to total, others zero | Naive states set to total, others zero | Naive states set to total, others zero | Naive states set to total, others zero |
Kim et al. [17] | CK_ini = 0.5, | CK_ini = 1, | CK_ini = 2, | CK_ini = 4, | CK_ini = 20, | CK_ini = 20, |
Lindskog et al. [18] | camkmax = 0.5, | camkmax = 1, | camkmax = 2, | camkmax = 4, | camkmax = 20, | camkmax = 20, |
Nakano et al. [19] | CaMKII = 0.12, PP1_active = 0.87, PP1_I1_p = 0.60 | CaMKII = 0.62, PP1_active = 1.87, PP1_I1_p = 1.60 | CaMKII = 1.62, PP1_active = 1.87, PP1_I1_p = 1.60 | CaMKII = 3.62, PP1_active = 0.29, PP1_I1_p = 0.18 | CaMKII = 19.62, PP1_active = 2.37, PP1_I1_p = 2.10 | CaMKII = 19.62, PP1_active = 0.87, PP1_I1_p = 0.60 |
Hayer and Bhalla [2] | basal_CaMKII_ PSD = 0.5, PP1-active_PSD = 2 | basal_CaMKII_ PSD = 1, PP1-active_PSD = 4 | basal_CaMKII_ PSD = 2, PP1-active_PSD = 4 | basal_CaMKII_ PSD = 4, PP1-active_PSD = 1 | basal_CaMKII_ PSD = 20, PP1-active_PSD = 5 | basal_CaMKII_ PSD = 20, PP1-active_PSD = 2 |
, CKCaM = 0.01, CKpCaM = 0.01
, CKCaM = 0.01, CKpCaM = 0.01
