Table 4 Comparison of the changes found using CBS and the proposed Bayesian-CPCM on the nine fibroblast cell lines
From: A Bayesian Analysis for Identifying DNA Copy Number Variations Using a Compound Poisson Process
Cell line/chromosome | CBS | Bayesian-CPCM approach | |
|---|---|---|---|
α = 0.01 | α = 0.001 | ||
GM01524/6 | Yes | Yes | Yes |
Number of false positives | 6 | 2 | 0 |
Specificity | 72.7% | 90.9% | 100% |
Sensitivity | 100% | 100% | 100% |
GM01535/5 | Yes | Yes | Yes |
GM01535/12 | No | No | No |
Number of false positives | 2 | 0 | 0 |
Specificity | 90.5% | 100% | 100% |
Sensitivity | 50% | 50% | 100% |
GM01750/9 | Yes | Yes | Yes |
GM01750/14 | Yes | Yes | Yes |
Number of false positives | 1 | 0 | 0 |
Specificity | 95.2% | 100% | 100% |
Sensitivity | 100% | 100% | 100% |
GM03134/8 | Yes | Yes | Yes |
Number of false positives | 3 | 1 | 3 |
Specificity | 86.4% | 95.5% | 97.9% |
Sensitivity | 100% | 100% | 100% |
GM03563/3 | Yes | Yes | Yes |
GM03563/9 | No | No | Yes |
Number of false positives | 8 | 5 | 0 |
Specificity | 61.9% | 76.2% | 100% |
Sensitivity | 50% | 50% | 100% |
GM05296/10 | Yes | Yes | Yes |
GM05296/11 | Yes | Yes | Yes |
Number of false positives | 3 | 0 | 2 |
Specificity | 88% | 100% | 99.3% |
Sensitivity | 100% | 100% | 100% |
GM07081/7 | Yes | Yes | Yes |
GM07081/15 | No | No | No |
Number of false positives | 1 | 0 | 0 |
Specificity | 95.2% | 100% | 100% |
Sensitivity | 50% | 50% | 100% |
GM13031/17 | Yes | Yes | Yes |
Number of false positives | 5 | 3 | 1 |
Specificity | 79.2% | 87.5% | 98.8% |
Sensitivity | 100% | 100% | 100% |
GM13330/1 | Yes | Yes | Yes |
GM13330/4 | Yes | Yes | Yes |
Number of false positives | 8 | 5 | 0 |
Specificity | 61.9% | 76.2% | 100% |
Sensitivity | 100% | 100% | 100% |