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Table 4 Comparison of the changes found using CBS and the proposed Bayesian-CPCM on the nine fibroblast cell lines

From: A Bayesian Analysis for Identifying DNA Copy Number Variations Using a Compound Poisson Process

Cell line/chromosome CBS   Bayesian-CPCM approach
  α = 0.01 α = 0.001  
GM01524/6 Yes Yes Yes
Number of false positives 6 2 0
Specificity 72.7% 90.9% 100%
Sensitivity 100% 100% 100%
GM01535/5 Yes Yes Yes
GM01535/12 No No No
Number of false positives 2 0 0
Specificity 90.5% 100% 100%
Sensitivity 50% 50% 100%
GM01750/9 Yes Yes Yes
GM01750/14 Yes Yes Yes
Number of false positives 1 0 0
Specificity 95.2% 100% 100%
Sensitivity 100% 100% 100%
GM03134/8 Yes Yes Yes
Number of false positives 3 1 3
Specificity 86.4% 95.5% 97.9%
Sensitivity 100% 100% 100%
GM03563/3 Yes Yes Yes
GM03563/9 No No Yes
Number of false positives 8 5 0
Specificity 61.9% 76.2% 100%
Sensitivity 50% 50% 100%
GM05296/10 Yes Yes Yes
GM05296/11 Yes Yes Yes
Number of false positives 3 0 2
Specificity 88% 100% 99.3%
Sensitivity 100% 100% 100%
GM07081/7 Yes Yes Yes
GM07081/15 No No No
Number of false positives 1 0 0
Specificity 95.2% 100% 100%
Sensitivity 50% 50% 100%
GM13031/17 Yes Yes Yes
Number of false positives 5 3 1
Specificity 79.2% 87.5% 98.8%
Sensitivity 100% 100% 100%
GM13330/1 Yes Yes Yes
GM13330/4 Yes Yes Yes
Number of false positives 8 5 0
Specificity 61.9% 76.2% 100%
Sensitivity 100% 100% 100%