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Table 4 Comparison of the estimated CMI of trivariate Gaussian distribution with different covariance matrices using Algorithm 2 and the modified b-spline algorithm.

From: Gene Regulatory Network Reconstruction Using Conditional Mutual Information

Cond. Corr.

Algorithm

100

200

300

400

500

Analytical

0

Adaptive

0.0263

0.0215

0.0171

0.0175

0.0113

0

 

b-spline 10

0.1899

0.1039

0.0711

0.0536

0.0429

 
 

b-spline 20

0.7888

0.5592

0.4330

0.3497

0.2943

 

0.1612

Adaptive

0.0310

0.0278

0.0253

0.0249

0.0187

0.0132

 

b-spline 10

0.1899

0.1065

0.0759

0.0603

0.0495

 

0.3035

Adaptive

0.0497

0.0510

0.0534

0.0565

0.0582

0.0483

 

b-spline 10

0.2251

0.1377

0.1032

0.0855

0.0761

 

0.7408

Adaptive

0.2294

0.3050

0.3234

0.3444

0.3784

0.3979

 

b-spline 10

0.2773

0.2390

0.2190

0.2092

0.2029

 
 

b-spline 20

0.6387

0.5323

0.4719

0.4378

0.4121

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